Clinician prescribed · Compounded semaglutide · Daily tablet

One tablet a day. No needles.

ONE is compounded semaglutide in a tablet that dissolves under your tongue. A licensed clinician prescribes it and adjusts your dose. Medication, shipping and your care team are one price.

See if you qualify $259/mo, everything included
  • Licensed clinicians, 50 states + DC
  • Full refund if not prescribed
  • Ships in plain packaging
What's in ONE

One active. One form. One rhythm.

Three things a clinician chooses for you, and why each one matters.

The active

Compounded semaglutide, a GLP-1 receptor agonist. It acts on the appetite signals between your gut and brain.

You feel full sooner and stay full longer.

The form

A small tablet you place under your tongue and let dissolve.

Nothing to inject, nothing to mix, no sharps to store or carry.

The rhythm

One tablet, once a day, at the same time you brush your teeth.

A daily habit instead of a weekly appointment with a needle. Your clinician steps the dose on your schedule.

1
tablet a day
0
needles
24h
clinician review, typically
1
price, everything included
Which fits your day

Injection or ONE?

Both are compounded semaglutide. Both are prescribed and adjusted by a licensed clinician. The difference is how it fits your day.

Weekly injection
ONE tablet
Form
Subcutaneous injection
Dissolves under the tongue
Rhythm
Once a week
Once a day
Needles
Yes, with sharps disposal
None
Monthly price
$209/mo
$259/mo

Both include the clinician review, clinician-directed dose changes, labs after you start and shipping. Your clinician can switch you either way at any refill.

Pricing

One price. Everything included.

Pay at checkout. If a clinician does not prescribe, you get a full refund. Nothing renews automatically.

ONE by Aevogen
Compounded semaglutide, sublingual tablet
$259/mo
from $159/mo on a 52-week plan
4-week supply$259/mo · one purchase
12-week plan$239/mo · $717 today
24-week plan$229/mo · $1,374 today
52-week plan$159/mo · $2,067 today
See if you qualify

Pay at checkout · full refund if not prescribed · nothing auto-renews

Important safety information ▾
  • Boxed warning: semaglutide caused thyroid C-cell tumors in rodents; it is not known whether it does in humans. Do not use with a personal or family history of medullary thyroid carcinoma or MEN 2.
  • Not for use in pregnancy or while breastfeeding; stop at least 2 months before a planned pregnancy.
  • Possible serious effects: pancreatitis, gallbladder disease, kidney injury from dehydration, low blood sugar when combined with insulin or sulfonylureas, severe allergic reaction, worsening diabetic eye disease, suicidal thoughts.
  • Common effects: nausea, vomiting, diarrhea, constipation, abdominal pain, reduced appetite, fatigue.
  • Compounded medication: prepared by a state-licensed pharmacy for you; not FDA-approved or evaluated for safety, effectiveness or quality.
Included in the price

Not a subscription to a website. A program.

  • Licensed clinician review of your intake, usually within 24 hours
  • Medication included when prescribed, shipped every 4 weeks
  • Labs ordered after you start, paid by the program
  • Dose adjustments and side-effect support from your care team
  • Unlimited messaging; video visit on request at no extra cost
How it works

Three steps. No waiting room.

Not prescribed? You get a full refund.

  1. 01

    Five-minute intake

    Tell us about your goals and health history. No appointment, no waiting room.

  2. 02

    Clinician review

    A licensed clinician reviews within 24 hours. A video visit only where your state requires it.

  3. 03

    Delivered

    If prescribed, medication ships in 2–4 days and refills ship every 4 weeks. Your care team is a message away.

Questions

About ONE

ONE is our name for the daily sublingual semaglutide program: compounded semaglutide in a tablet that dissolves under the tongue, prescribed by a licensed clinician, with medication, shipping and care-team support included in one price. The medication itself is labelled by the pharmacy as compounded semaglutide.

Both contain compounded semaglutide. The tablet is taken daily under the tongue; the injection is weekly. Your clinician decides which form and dose is appropriate for you and can switch you at a refill.

No. ONE is a compounded medication, prepared by a state-licensed pharmacy for an individual patient. Compounded medications are not reviewed by the FDA for safety, effectiveness or quality. Where a brand-name, FDA-approved option is appropriate, your clinician will tell you.

Adults 18 to 74 with a BMI of 27 or higher, or 25 or higher with a weight-related condition. Not for use in pregnancy or while breastfeeding, or with a personal or family history of medullary thyroid carcinoma or MEN 2. The clinician makes the final call from your intake.

You get a full refund. You pay at checkout; if the clinician decides ONE is not right for you, the payment is returned in full and you are offered a call with the care team.

See if ONE is right for you.

A licensed clinician reviews every order. Medication, shipping and your care team are included.

See if you qualify

The assessment on this website does not create a doctor–patient relationship between the individual completing it and Aevogen. Independent, US-licensed clinicians in our clinical partner network apply exclusionary criteria to determine whether an individual is a candidate for a given medication; the answers you provide may screen you out of eligibility, and a clinician reviews every order after checkout to decide whether a prescription is appropriate. Clinicians retain the sole decision to prescribe. No prescription is guaranteed; if a clinician does not prescribe, you receive a full refund.

Compounded medications are prepared by state-licensed pharmacies for an individual patient. Although these facilities are regulated, compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness, or quality. The decision to use a compounded medication is guided by the licensed clinician's medical judgment, informed by your telehealth intake and medical history. Where a brand-name, FDA-approved medication is appropriate, your clinician will tell you.

Aevogen does not produce or dispense medication and is not a pharmacy. Medical treatment is provided by independent, licensed clinicians through affiliated professional corporations in our clinical partner network. You may receive medication that looks different from what is portrayed on this website. Medication is included in the cost of the program.

Certain images and text on this website are generated or enhanced with artificial intelligence and are illustrative; individuals shown are not patients. Any patient statements published on this site are from real patients with their written authorization, and images representing them may use models. Individual results vary and depend on adherence to your clinician's plan. Consult a healthcare professional before starting any medication.

By accepting our Terms of Use you understand that you may enter into a relationship with a licensed partner pharmacy that dispenses your medication. Partner pharmacies are identified in your account and in the Terms of Use. If you are experiencing a medical emergency, call 911.